Treatment of primary erythromelalgia with cyclosporine.

A 28-year-old woman presented with severe, persistent burning pain in the legs and feet, with marked erythema, swelling, and warmth (Fig. 1, left-hand panels). The erythema had begun at the age off our years, with no associated disorder. After adolescence, the symptoms became continuous, with erythema that extended to the thighs and the development of live do-like lesions. Burning pain during the night was relieved only by immersion of the affected areas in ice water. No treatment relieved her symptoms, which were due to autosomal dominant erythromelalgia. [1] Her older sister and eight year-old daughter also had this disorder.